The fate of certain organic acids and amides in the rabbit. 5. o- and m-hydroxybenzoic acids and amides
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The fate of certain organic acids and amides in the rabbit; nitrobenzoic acids and amides.
Studies in vitro (Bray, James, Ryman & Thorpe, 1948a) have shown that rabbit-liver extracts are able to hydrolyze all three nitrobenzamides. The para isomer is most readily attacked, the average hydrolysis being 82 %; under the same conditions the meta and ortho isomers are hydrolyzed to the extent of 31 and 23 %, respectively. It was, therefore, of interest to study the metabolism of these com...
متن کاملThe fate of certain organic acids and amides in the rabbit. 12. Aminohydroxybenzoic acids.
Colin, H. & Chaudin, A., (1933a). Bull. Soc. Chim. biol., Paris, 15, 402. Colin, H. & Chaudin, A. (1933b). Bull. Soc. Chim. biol., Paris, 15, 1520. Euler, H. v. & Erdtmann, H. (1925). Hoppe-Seyl. Z. 145, 261. Hibbert, H. & Brauns, F. (1931). Canad. J. Res. 4, 596. Hirst, E. L., McGilvray, D. I. & Percival, E. G. V. (1950). J. chem. Soc. p. 1297. Hirst, E. L. & Young, G. T. (1938). J. chem. Soc....
متن کاملThe fate of certain organic acids and amides in the rabbit: 3. Hydrolysis of amides by enzymes in vitro.
Carson, J. F. & Maclay, W. D. (1946). J. Amer. chem. Soc. 68, 1015. Chamberlain, N. H., Cunningham, G. E. & Speakman, J. B. (1946). Nature, Lond., 158, 553. Elson, L. A. & Morgan, W. T. J. (1933). Biochem. J. 27, 1824. Haas, E. (1946). J. biol. Chem. 163, 63. Hadidian, Z. & Pirie, N. W. (1948). Biochem. J. 42, 260. Hahn, L. (1945). Ark. Kemi Min. Geol. 19 A, no. 33. Hobby, G. L., Dawson, M. H.,...
متن کاملThe Fate of Certain Organic Acids and Amides in the Rabbit
1. Sulphapyridine containing 35S has been synthesized. 2. Metabolic experiments with this compound in the rabbit have shown that there is no complete catabolism to inorganic sulphate and no significant retention of the drug in the tissues after 3 days. 3. Differences between the values obtained by assays of 3S and diazotizable material suggested the formation of a metabolite which does not diaz...
متن کاملThe Fate of Certain Organic Acids and Amides in the Rabbit
We have already reported (Bray, Ryman & Thorpe, 1947) upon the fate ofp-hydroxybenzoic acid and its amide in the rabbit. The present paper gives the corresponding results for the oand m-isomers. The changes which these compounds might undergo are theoretically the same as those for the p-isomer, i.e. the hydroxyl group may be conjugated with either glucuronic or sulphuric acids and the carboxyl...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1948
ISSN: 0306-3283
DOI: 10.1042/bj0430561